Lancashire Times
Weekend Edition
10:19 AM 4th June 2020

HPV Vaccine Manufacturers Commit To Provide Enough Supply To Immunise At Least 84 Million Girls In Gavi Countries

On the eve of the Global Vaccine Summit 2020, five manufacturers commit to increasing and prioritising HPV vaccine supply to Gavi-supported countries, which have among the highest cervical cancer burdens in the world

Gavi estimates that up to 84 million girls in the poorest countries could receive HPV vaccines in the next 5-year period, averting 1.4 million future cervical cancer deaths

Dr Seth Berkley: “We are extremely grateful to MSD, GSK, Innovax, Serum Institute of India Pvt. Ltd. and Walvax for these commitments, which should have a profound impact on women’s lives”

Vaccine manufacturers MSD, GSK, Innovax, Serum Institute of India Pvt. Ltd. (SII) and Walvax have pledged to ramp up human papillomavirus (HPV) vaccine supply availability for Gavi-supported countries, ahead of today’s Global Vaccine Summit 2020.

This commitment is part of an ongoing UNICEF-led tender that aims to enable Gavi to dramatically increase its reach from 50 million girls, as initially planned, to 84 million girls during the next five-year period, leading to the prevention of an estimated 1.4 million future deaths from cervical cancer.

“We are extremely grateful to MSD, GSK, Innovax, Serum Institute of India Pvt. Ltd. and Walvax for these commitments, which should have a profound impact on women’s lives in the poorest countries of the world,” said Dr Seth Berkley, CEO of Gavi, the Vaccine Alliance.

“HPV is one of the most impactful vaccines in the Gavi portfolio, and country demand is currently far in excess of supply. Today’s commitment has the potential to save more lives, and to take significant steps towards our common goal of a world free of cervical cancer.”

Gavi’s initial target to vaccinate 40 million girls between 2016 and 2020 was reduced to 14 million due to increasing global demand for, and limited supply of, HPV vaccine. For its 2021–2025 period, Gavi had initially forecasted that only 50 million girls would have access to the vaccine (out of the 84 million girls who could have been reached with unconstrained supply).

Currently, only two manufacturers, MSD and GSK, produce WHO-prequalified HPV vaccines.

Several others are developing HPV vaccines – including Innovax (whose vaccine is currently under review for WHO prequalification), as well as Serum Institute of India and Walvax. UNICEF issued a tender in December 2019 for additional supply of quality-assured, WHO-prequalified vaccines to Gavi-supported countries and Gavi-transitioned countries for 2021 and beyond.

“This commitment is excellent news for millions of girls, as access to the HPV vaccine can make a difference between life and death,” said Etleva Kadilli, Director of UNICEF’s supply and procurement headquarters.

“Limited vaccine supply has been a great concern for UNICEF, as it often means that the most vulnerable populations are left behind. The increase in production and affordable pricing means that more countries will be able to make this life-saving investment and introduce HPV vaccines into their routine immunisation programmes.”

Cervical cancer is the second-most common form of cancer in women living in less-developed regions. Eighty-five percent of global cervical cancer cases occur in low-income countries (LICs) and middle-income countries (MICs), with sub-Saharan Africa and Asia accounting for the highest incidence rates.

To date, Gavi has helped 30 countries introduce HPV vaccine demonstration programmes, and 191 have successfully introduced the vaccine nationally. Five of them, Malawi, Tanzania, Uganda, Zimbabwe and Zambia, carry among the 10 highest cervical cancer burdens in the world.

The UK Government will host the Global Vaccine Summit 2020, Gavi’s third investment conference, to raise at least US$ 7.4 billion in additional resources for the next five years to protect the next generation with vaccines, reduce disease inequality and create a healthier, safer and more prosperous world.

Representatives from over 50 countries, including over 25 heads of state, will participate in this virtual event, which will be livestreamed on our homepage. It will be a major opportunity for world leaders to reiterate their support for Gavi’s vision to immunise an additional 300 million children, saving up to 8 million lives by 2025.